While this post is going to be pretty brief, I have been toying with kratom potentiators for the last few months and have had some pretty good results. Here are some of the top potentiators that I’ve used.
White Grapefruit Juice
Certain compounds in white grapefruit (especially in the rind), are quit good at inhibiting certain enzymatic processes. One of such enzymes is responsible for breaking down the active alkaloids in kratom. Because of this, using grapefruit can not only potentiate kratom, by slowing down the break-down process, but also make the experience last longer.
Cat’s claw is a fairly effective anti-depressant and anxiety reducer in itself, but the primary purpose for using it in potentiation is that it is a NMDA agonist. Like many other NMDA agonists, the can reduce and prevent the build up of tolerance. If taken for a few weeks alongside kratom extract, you may see a significant increase in potency of kratom — definitely good for improving the pain relief properties of kratom.
While I’m not sure of the exact mechanism of action of Ashwagandha, besides its activity at the gaba receptors, I have had great experiences mixing it with kratom. For me it tends to make my burns more energetic and clean, and last longer. Definitely worth a shot, as it is a great herb on its own — definitely worth taking daily.